Oxytocin protects neurons from hypoxic-ischemic brain injury by enhancing inhibitory neurotransmission in neonatal rats

Purpose: To study the protective effect of oxytocin on hypoxic-ischemic brain neuron injury in neonatal rats, and mechanism action involved.Methods: Hippocampal slices from SD rats were cultured oxygen/glucose-deprived (OGD) solution, leading to establishment model hippocampal vitro. The assigned 3 groups: control (ACSF solution), (OGD solution + 1 μM oxytocin). vertebral neurons CA1 region HIBD was determined using TOPRO-3 staining, while effects hypoxic depolarization (AD) inhibitory postsynaptic currents (iPSCs) measured by cell patch clamp technique.Results: fluorescence intensity lamina area group significantly higher than that group, corresponding value for lower (p < 0.05). time lapse before occurrence AD longer neuronal receptor antagonist group. frequency amplitude iPSCs markedly values.Conclusion: Oxytocin exerts against damage regulating activation GABA receptor, inhibiting nerve transmission. These findings may be benefit development a suitable therapy HIBD.